Curcumin’s Effect on Viruses and Bacteria

Curcumin has long been known for its traditional uses as an antimicrobial. It has been known to have therapeutic results as an effective antiviral. Studies have shown that it is active against the hepatitis B and C virus.

Hepatitis infection are characterized by the inflammation of the sufferer’s liver.  This inflammation is the result of the virus infiltrating the liver and utilizing the host as a tool for both propagation and gene expression.  Effective antiviral strategies thus far have focused on the host factors. Host factors are the elements that the virus requires for survival and multiplication.

 Curcumin can be a useful tool at inhibiting gene expression and viral replication concerning some hepatitis viruses, including hepatitis B. This  is accomplished through the down-regulation of a protein which is typically induced by starvation. The protein is known as peroxisome-activated receptor gamma coactivator 1-alpha, orPGC-1 alpha for short, and is encoded by the human gene designated PPARGC1A. It is responsible for the initiation of gluconeogenesis cascades and has been demonstrated to be a co-activating element in the transcription of the hepatitis B virus.

Again, upon investigating the antiviral properties of Curcumin, we find that it suppresses an blocks pathogenic pathways to the cell and deactivates protein that are used by antagonist viruses to regenerate and replicate, causing apoptosis and cell death to host tissue. Curcumin has played a useful role in sterilizing viruses, including many strains of hepatitis, and has also shown to be effective against the herpes simplex virus variations. It may play a future role as a preventive therapy measure for sexually transmitted diseases.  It was tested against HIV, but did not show an improvment or decline, which inthe case of HIV, is likely a good sign.

 Bacteria  

Curcumin has traditionally been known for its antibacterial effectiveness in wounds, infections of the body and eyes, internal infections, and for purifying food and water, and minerals.   A study used a Curcumin compound with four herbs; Curcumin  longa L, areca catechu, Oryza sativa, and Garcinia mangostana L., combined with an ethanol extract,  respectively called THR-SK 010.  The experiment was conducted against Staphylococcus aureus and susceptible S. aureus.

 Conclusions for this experiment showed remarkable antibacterial, antiinflammatory, and antioxidant activities, as well as low toxicity and Vero cells of  THR-SK 0101 as an ethanol extract formula. This information supports the topical use of the method for wound treatment.Other studies showed similar results regarding the effectiveness of Curcumin.  Curcumin breaks up bacteria. It is effective against various forms of staph infection, strep, E. coli, and salmonella, among others. Historically, the primary use of Cucumin was an agent to sanitize infectious injuries and wounds, to prevent infection, and fight toxins. Other applications have been used to treat food and water, surfaces, and sanitize textiles.

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