Curcumin in Neurological and Vascular Studies

Research Example 4  

Over 35 million people are affected by various forms of dementia, 60% of which are attributed to Alzheimer’s disease.  More than 71 million people are expected to be affected by dementia over then ext several.  Dementia is a condition that is characterized by symptoms affecting behavior, memory, cognition.  There are numerous forms of dementia, but Alzheimer’s disease the most common.  It is distinguished from other types of dementia disorders by several features, including neural loss and neurofibrillary tangles. Senile plaques are another feature associated with this condition.

Dementia is a condition that is characterized by symptoms affecting behavior, memory, cognition.  There are numerous forms of dementia, but Alzheimer’s disease the most common.  It is distinguished from other types of dementia disorders by several features, including neural loss and neurofibrillary tangles. Senile plaques are another feature associated with this condition.

Two distinct proteins related to Alzheimer’s  disease progression have been identified, amyloid-B-protein (AB) and tau.  Amyloid-B-protein in responsible for impairment as fibrils and oligomers in the cerebral vasculature as well as in the brain parenchyma. This particular protein is also responsible for tau hyperphosphorylation, which has negative outcomes including disruption of the mitochondrial membrane. In this condition, tau can also form neurofibrillary tangles via aggregation; both of these outcomes can result in apoptosis. Tau and amyloid-B-protein represent the main components of the neurofibrillary tangles in the Alzheimer’s afflicted brain and are also the primary elements present in senile plaques.  

There are only a limited number of drugs that have demonstrated any demonstrated any effectiveness in slowing or stopping Alzheimer’s disease, and that effectiveness itself has been severely limited. This has led to an increased interest in natural antioxidants and Curcumin.

Curcumin has properties that prevent neural cells from aggregating or clumping together. Curcumin was shown to protect cells against AB toxicity and reduce tau hyperphosphoryation.  Additionally, Curcumin can be of assistance in amyloid precursor protein (APP) cleavage, and in the reduction of amyloid-B=protein-induced radical oxygen species. In experiments that examined the restoration of synaptic plasticity in slices of rat hippocampus,  the addition of Curcumin to AB oligomer treated samples was satisfactory due to the long-term potentiation enhancement.

 

Additionally, Curcumin can be of assistance in amyloid precursor protein (APP) cleavage, and in the reduction of amyloid-B=protein-induced radical oxygen species. In experiments that examined the restoration of synaptic plasticity in slices of rat hippocampus,  the addition of Curcumin to AB oligomer treated samples was satisfactory due to the long-term potentiation enhancement. Even the use of dietary Curcumin in relatively small 160ppm doses was demonstrated to effective in the reduction of inflammation and in decreasing brain-oriented oxidative stress in genetic mice models over a period of only six months.

Even the use of dietary Curcumin in relatively small 160ppm doses was demonstrated to effective in the reduction of inflammation and in decreasing brain-oriented oxidative stress in genetic mice models over a period of only six months. Similar studies which focused on orally-ingested Curcumin treatments were shown to reduce AB levels in the same models, in addition to reducing plaque burden.

Another mouse model devised for Alzheimer therapy experimentation demonstrated Curcumin’s effectiveness in clearing deposits of amyloid-B-protein through intravenous (IV)  Curcumin treatment after only a week of daily treatments of 7.7 mg. The experiment also determined the effectiveness of Curcumin crossing the blood-brain barrier in this model.  In these studies and others, the unique factor is that Curcumin has properties that prevent cells from clumping, clotting, or forming together, which produces a mass called an aggregation. When this clumping is avoided in the brain, it prevents rogue proteins from forming little webs of scar tissue-like material.

 In these studies and others, the unique factor is that Curcumin has properties that prevent cells from clumping, clotting, or forming together, which produces a mass called an aggregation. When this clumping is avoided in the brain, it prevents rogue proteins from forming little webs of scar tissue-like material. Abstractly, that causes a tangling of nerve synapses (nerve ending) and damage to energy producing mitochondria (energy producers of the cell), inducing neural damage and cell death.

The brain acts like a sink clog, you get one piece pf junk (rogue protein) lodged in the drain (nerves), then it starts collecting other junk, and it all gets wrapped around each other. It is tough to dissolve, and as water keeps pouring through slower and slower, a clog (neuro-tangle) develops. When a clog develops, water cannot pass through (normal nerve and information gathering) and then you will need a drain cleaner (Curcumin, protein regulator, anti-inflammatory). That is how neuro-tangles form. Curcumin stops this from happening and helps remove the tangle after it forms. Curcumin has been found to have neurogenesis properties among brain cells, which causes them to regenerate. This has been discovered in the cell process of protein folding.

Curcumin has been found to have neurogenesis properties among brain cells, which causes them to regenerate. This has been discovered in the cell process of protein folding. When cells are cells are stressed signals are sent to the proteins that build healthy cells. Folding becomes rushed and irregular, and cell abnormalities begin to develop. Curcumin regulates the production of these cells and slows the process down, allowing protein folding to reorganize and start folding in a normal, healthier state, producing healthier cells.

Conceptually, proteins are like workers in a factory trying to keep up with an excess perceived demand for a product (cells). They begin making the product too fast and skip steps, which undermines the integrity (abnormalities and mutagens) of the product. This causes the company. A new supervisor (Curcumin) steps in and issues instructions that bring the production rate down to normal to provide a better quality product. This eliminates the substandard product from the shelf and redeems the company’s market value. Curcumin is among the few substances known to cross the blood-brain barrier. This is important in understanding why nutrients we think are getting to the brain are not. The function of the blood-brain barrier is important because it prevents neurotoxins from getting into the brain cells and causing damage, but sometimes it does the reverse and keeps good things out. It is important to note that brain disorders have been linked to decreased BDNF (brain-derived neurotrophic factors), which is a growth hormone that functions in the brain and keeps it from withering away. Alzheimer’s disease and depression have been linked to this decreased hormone level. Curcumin has been shown to increased the brain’s level of BDNF. This promotes the growth of new neurons and fights degenerative processes in the brain.

It is imperative to note here that research has discovered evidence that Curcumin products have been shown to reverse dementia and Alzheimer’s disease in patients. Patients who no longer recognize their families, after taking Curcumin for one year, were able to identify them again. Curcumin was found to enhance the brain repair mechanism and prevent neuro-plaque, or protein build up. Similar results were noted in epilepsy patients. It was found that Curcumin prevented mitochondrial (mitochondria – cell energy supply organelle) damage, stress oxidation, and improved cognitive ability.  Additionally, Curcumin also acts in a similar fashion in regards to depression and chronic stress. Most people do not realize that brain cells become damaged by chronic stress and depression. Curcumin has traditionally been known and used to promote feelings of well-being. Recently, it has been brought to the public

 Additionally, Curcumin also acts in a similar fashion in regards to depression and chronic stress. Most people do not realize that brain cells become damaged by chronic stress and depression. Curcumin has traditionally been known and used to promote feelings of well-being. Recently, it has been brought to the public attention and even mentioned on Dr. Oz that studies have proven it is just as effective as Prozac as well as many other antidepressants and psychoactive drugs, without the accompanying negative side-effects,

Also, Curcumin has shown to act in a similar fashion in regards to vascular health because of its anti-clumping or anti-aggregation agents. Curcumin’s anti-inflammatory and antioxidant properties inhibit the clumping of cells and proteins, and it has been shown to prevent plaque from forming, clotting, or clumping within the blood vessels and heart. This makes Curcumin very useful in the prevention of heart disease, stroke, deep vein thrombosis, and aids in vascular health. Many studies indicate that Curcumin produces improved function of the endothelium. The endothelium regulates blood pressure and blood clotting as well as other

Many studies indicate that Curcumin produces improved function of the endothelium. The endothelium regulates blood pressure and blood clotting as well as other factors. Curcumin regulates inflammation and oxidation and has anti-aggregation properties that have been shown to work as well as some other drugs. Research Example 5

Research Example 5

 Hyperglycemia is known to increase oxidative stress resulting in endothelial dysfunction. A study was carried out to compare the effects of NCB-02  (a standardized preparation of curcumoids), atorvastatin, and placebos in specific function and biomarkers in patients with type ll diabetes mellitus.

 A randomized group of type II diabetes patients, 72 in total, were selected to receive a treatment that included twice daily dosages of Curcumin, or a single daily dose of atorvastatin, or a placebo over a period of two months. NCB-02 was a designation for the Curcumin element of the treatment, which consisted of two 150 mg capsules of Curcumin . The atorvastatin dose was 10 milligrams. The study was completed by a majority (67) of the subjects. Baseline comparisons showed endothelial function improvement at a significant level with the 10 mg atorvastatin regimen. Compared to this treatment, the Curcumin therapy was even more efficient when tracking the reduction of cell signaling proteins known as cytokines, responsible inflammation. Oxidative stress markers were also reduced. The group receiving a placebo treatment did not demonstrate any significant improvement. What this describes is how Curcumin improves vascular function with the tissues (endothelium) of blood vessels by regulating rogue proteins and blocking their signaling pathways, which is important to adequate blood circulation. It is very common to find instances in which diabetic patients lose their toes, feet or legs because of the lack of circulation in their lower extremities. Because they cannot feel their extremities because nerve response is inhibited, small injuries can lead to horrible infections and gangrene.

 This is where Curcumin is helpful on three counts- it aids vascular function by eliminating plaque, it aids in nerve regeneration, and it helps in fighting microbial infections.

 

                                                                                                                      

 

 

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