Curcumin in Antifungal and Anti-Parasitic Studies

Curcumin is known as a polyphenol.  Polyphenols are secondary metabolites abundant in plant-derived foods. The aim of this study was to evaluate the antifungal potential of polyphenols against Candida albicans biofilms.  The antifungal activity of 14 different polyphenol varieties was accessed concerning planktonic and sessile minimum inhibitory concentrations against various Candida albicans, adhesion, The most active, polyphenols were further tested for their effect Candida albicans, adhesion, and biofilm growth, using standard biomass assays, polyphenols microscopically, and quantitive gene expression. Of the 14 tested, seven were effective inhibitors of planktonic growth, of which pyrogallol was the most efficient, followed by Curcumin and pyrocatechol. Both pyrogallol and Curcumin displayed superior biofilm activity, inhibiting initial cell adhesion following pre-coding, biofilm growth, and gene expression. Inhibitory effects of antagonists diminished with prolonged Curcumin exposure. Overall, Curcumin exhibited active anti-biofilm properties that can be used as the foundation for development into similar molecules. This study expresses that Curcumin was tested

This study expresses that Curcumin was tested alongside 14 other polyphenols, or plant-derived compounds, of which 7 yielded affirmative results in eliminating the contaminating factors found in a biofilm, which is essentially a slime, or mucus-like substance.  The biofilm was infected with Candida albicans, a yeast organism,  and experiments were performed to conclude which polyphenols worked the best.  Curcumin came in at second best but was still showing superior organism elimination of the Candida albicans variety. Something to note from th is study in comparison to other studies that we have investigated for this book is Curcumin’s anti-clumping ability. It prevented Candida from adhering to each other, which minimizes the organisms’ defenses. Curcumin is also an excellent synergist to use with photo-light therapies against Candida yeast.                                                     

Curcumin is also an excellent synergist to use with photo-light therapies against Candida yeast.   Although regarded as a fungus, it is also somewhat of a parasite. There are different variations of Candida, and the little fungi can be found floating around like lumpy potatoes in the blood. The problem is that as a living organism it produces waste products, essentially pooping in the blood stream. This can create some toxic effects that lead to depression, confusion, autoimmune disorders. and fatigue if it gets out of control. The problem with Candida in the United States is that it is not usually tested for; there is no standardized tests or doctors mentioning it as a possible affliction. Many people have it without ever knowing they are infected, and they can feel sick without knowing why. This condition can even go untreated forever as it is not readily recognized. Candida and many other parasitic conditions are more rampant in the United States than people realize.

Curcumin has been a valued antifungal and anti-parasitic agent for thousands of years. Studies of Curcumin’s effectiveness against Candida strains have been conducted, revealing that it is a deadly threat to the survival of this organism.

Curcumin has also been found to be very effective in the elimination of mold as well as against other types of parasites, especially roundworm and drug-resistant forms of malaria when used synergistically with anti-parasitic drugs.                                                 

 

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